RNA Details
Disease Name
diabetic nephropathy
Tissue
kidney
RNA Symbol
mir-142a
RNA ID
RNA Type
miRNA
Alteration Pattern
down regulation
Species
mus musculus
Detection Methods
qPCR; dual-luciferase reporter assay; Masson's trichrome staining etc.
Target
PTEN
Pathway
PI3K-AKT SIGNALING PATHWAY
PubMed ID
Title
Oleanolic acid attenuated diabetic mesangial cell injury by activation of autophagy via miRNA-142-5p/PTEN signaling
Year
2019
Function
Oleanolic acid alleviated diabetic renal fibrosis by increasing autophagy through regulation of miR-142-5p/PTEN via PI3k/Akt/mtor pathway in nrk-52e cells.